Kamagra Oral Jelly
Kamagra gel (sildenafil)
Oral jelly with tropical fruit flavor: pineapple and orange 100 mg.
5 g contains active substances – sildenafil citrate 140.480 mg (equivalent to 100 mg of sildenafil). Homogeneous jelly of orange color (with orange flavor) or yellow color (pineapple flavor), with a sweet taste and pleasant smell.
Excipients: sucrose, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, acesulfame potassium, sodium chloride, propylene glycol, liquid sorbitol, sodium carmellose, anhydrous citric acid, citric acid monohydrate, flavors, purified water.
Kamagra Oral Jelly 100 mg
Pharmacotherapeutic group – treatment of erectile dysfunction. Sildenafil.
Erectile dysfunction is characterized by the inability to achieve or maintain a penile erection sufficient for satisfactory intercourse.
Kamagra is rapidly absorbed. Peak plasma concentrations are reached within 30-120 minutes (median 60 minutes) after ingestion on an empty stomach. When taking sildenafil with a fatty meal, the degree of absorption is significantly reduced, with an average delay of 60 minutes and an average decrease in Cmax by 30%. Sildenafil and its main circulating metabolite, N-desmethyl, are approximately 96% bound to plasma proteins. Plasma protein binding depends on the total concentration of the drug.
Kamagra Oral Jelly – pharmacodynamics
Kamagra contains sildenafil citrate, a selective cyclic guanosine monophosphate (cGMP) inhibitor specific for phosphodiesterase type 5 (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide into the cavernous body of the penis during sexual arousal. Nitric oxide then activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate (cGMP), causing relaxation of the smooth muscles of the corpora cavernosa and allowing blood flow. The drug does not have a direct relaxing effect on the cavernous bodies but enhances the effect of nitric oxide by inhibiting type 5 phosphodiesterase (PDE5), which is responsible for the breakdown of cGMP in the cavernous bodies. When osteoarthritis is released locally during sexual arousal, PDE-5 inhibition by the drug causes an increase in cGMP levels in the corpus cavernosum of the penis, resulting in smooth muscle relaxation and blood flow to the corpus cavernosum. Kamagra in the recommended doses does not cause an erection in the absence of sexual arousal.
The sachet is for single use – open the sachet and use the entire contents. Kamagra should be taken as needed about an hour before sexual intercourse. The recommended dose of the drug is 50 mg and is taken before meals. Depending on the effectiveness and tolerability of the drug, its dose may be increased to 100 mg or reduced to 25 mg. The maximum recommended dose of the drug is 100 mg per day. The maximum recommended frequency of taking the drug is 1 time per day.
In elderly patients, dose adjustment of the drug is not required.
To diagnose erectile dysfunction, determine its possible causes and select adequate treatment, it is necessary to collect a complete history and conduct a thorough physical examination. Sexual activity poses a certain risk in the presence of heart disease, so before starting any therapy for erectile dysfunction, the doctor should conduct an examination of the cardiovascular system. Pharmaceutical preparations intended for the treatment of erectile dysfunction should not be prescribed to men for whom sexual activity is undesirable.
Kamagra Oral Jelly Side Effects
- had an aunt;
- color distortions of vision, blurred vision;
- hyperemia, hot flashes;
- nasal congestion;
- dyspepsia, nausea.
- dry eyes, eye pain, photophobia;
- noise in ears;
- tachycardia, palpitations;
- high blood pressure, low blood pressure;
- nose bleed;
- myalgia, pain in the extremities;
- chest pain, feeling hot.
Effect of other drugs on sildenafil
With the simultaneous administration of sildenafil with ketoconazole, erythromycin, or cimetidine, a decrease in the clearance of sildenafil is observed. In this group of patients, there is no increase in the frequency of side effects, but it is necessary to start treatment with Kamagra at an initial dose of 25 mg.
Grapefruit juice is a weak inhibitor of CYP3A4-mediated metabolism in the gut wall and may cause a moderate increase in sildenafil plasma levels.
A single dose of an antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of sildenafil.
Tolbutamide, warfarin and phenytoin, thiazide and thiazide-like diuretics, loop and potassium-sparing diuretics, calcium channel blockers, and beta-adrenergic receptor blockers do not affect the pharmacokinetics of sildenafil.
Can Kamagra and Cialis be taken together?
Simultaneous use with other PDE-5 inhibitors or other erectile dysfunction treatments. The safety and effectiveness of sildenafil in combination with other PDE-5 inhibitors or other drugs containing sildenafil for the treatment of pulmonary arterial hypertension or other drugs for the treatment of erectile dysfunction n have not been studied. In this regard, the use of such drug combinations is not recommended.
Sildenafil is able to enhance the hypotensive effect of nitrates, namely a significant decrease in blood pressure. Therefore, its simultaneous use with nitric oxide donors (amyl nitrite) or nitrates in any form is contraindicated.
Simultaneous reception with alpha-blockers
It is recommended to use sildenafil with caution in patients taking drugs from the group of alpha-blockers, since their simultaneous use can lead to symptomatic arterial hypotension in some susceptible patients. Most likely, this can be observed within 4 hours of taking a dose of sildenafil. To reduce the risk of developing orthostatic arterial hypotension, a stable hemodynamic state should be achieved in patients receiving therapy with alpha-blockers before initiating treatment with sildenafil. The possibility of using sildenafil should be considered, starting with a dose of 25 mg. Additionally, clinicians should instruct patients on what to do if symptoms of orthostatic hypotension develop.
- Sildenafil ( Kamagra at a dose of 50 mg) does not contribute to the increase in bleeding time caused by taking acetylsalicylic acid (at a dose of 150 mg).
- Sildenafil (at a dose of 50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers at a mean maximum blood alcohol level of 80 mg/dL.
Clinical studies have shown that sildenafil has a systemic vasodilating effect, causing a transient decrease in blood pressure. In most patients, this has little or no effect. However, before prescribing sildenafil, the likelihood of undesirable consequences of the vasodilating effect of this drug should be carefully checked. The vasodilator hypersensitivity group includes patients with left ventricular outflow narrowing (eg, aortic valve stenosis, hypertrophic obstructive cardiomyopathy).
It is recommended to use sildenafil with caution in patients taking drugs from the group of alpha-blockers, since their simultaneous use can lead to symptomatic arterial hypotension in some susceptible patients. In order to reduce the risk of developing orthostatic arterial hypotension, the condition of patients receiving alpha-blockers should be stable before starting treatment with sildenafil. The advisability of starting treatment with low doses of sildenafil should be considered. Additionally, clinicians should counsel patients on what to do if symptoms of orthostatic hypotension develop.
A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of retinal phosphodiesterase functions. Information on the safety of sildenafil in patients with retinitis pigmentosa is not available, so sildenafil should be used with caution.
Drugs for the treatment of erectile dysfunction should be used with caution in patients with anatomical deformities of the penis (such as angulation, cavernous fibrosis, or Peyronie’s disease), as well as in patients with diseases predisposing to the development of priapism.
The safety and effectiveness of sildenafil in combination with other erectile dysfunction treatments have not been studied and the use of these drug combinations is not recommended.
When taking Kamagra, no negative effects on the ability to drive a car or other technical means have been observed, however, given the side effects of the drug, care should be taken when driving vehicles or other potentially dangerous mechanisms.
When taking high doses of Kamagra, there may be an increase in side effects seen when taking the recommended doses. In case of overdose, general symptomatic and supportive treatment is prescribed.